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Nat Med. 2001 May;7(5):541-7.

The cellular neurobiology of depression.

Author information

1
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA. manjih@intra.nimh.nih.gov

Abstract

Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.

PMID:
11329053
DOI:
10.1038/87865
[Indexed for MEDLINE]

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