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J Nat Prod. 2001 Apr;64(4):527-30.

New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum.

Author information

1
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsststrasse 1, D-40225 Düsseldorf, Germany.

Abstract

Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods.

PMID:
11325242
[Indexed for MEDLINE]

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