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Carbohydr Res. 2001 Mar 22;331(2):119-27.

Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling.

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1
Department of Biology and Biochemistry, University of Bath, Claverton Down, UK.

Abstract

New diazirine based bis-glucose derivatives for tagging glucose transporters have been synthesised. These included two biotinylated compounds linked either by an aminocaproate or by a cleavable dithiol link. These compounds have been derivatised via a key skeleton compound that can be easily used for introduction of additional tags. Studies on the erythrocyte glucose transporter (GLUT1) and the insulin-stimulated adipose cell transporter (GLUT4) have revealed the biotinylated photoreactive bis-glucose compounds are effective labelling reagents.

PMID:
11322726
[Indexed for MEDLINE]
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