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J Mol Microbiol Biotechnol. 2001 Apr;3(2):215-8.

AcrAB and related multidrug efflux pumps of Escherichia coli.

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Department of Molecular and Cell Biology, University of California, Berkeley 94720-3206, USA.


The AcrAB system of Escherichia coli is a multidrug efflux system composed of an RND-type transporter AcrB and a periplasmic accessory protein AcrA, and pumps out a wide variety of lipophilic and amphiphilic inhibitors directly into the medium, presumably through the TolC outer membrane channel. AcrA, a highly elongated protein, is thought to bring the outer and inner membranes closer. It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the.

[Indexed for MEDLINE]

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