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Anal Chem. 2001 Apr 1;73(7):1399-402.

Nanoscale atmospheric pressure laser ablation-mass spectrometry.

Author information

1
Department of Chemistry, Swiss Federal Institute of Technology (ETH), Zürich.

Abstract

We describe an atmospheric pressure nanosampling interface for mass spectrometry based on near-field laser ablation. Pulsed laser radiation is delivered to the sample surface through a near-field optical probe, and the ablation plume is sampled through a capillary orifice and analyzed by standard MS methods. A spatial resolution of less than 200 nm and a sensitivity below 2 amol is demonstrated.

PMID:
11321286
DOI:
10.1021/ac001440b

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