Format

Send to

Choose Destination
See comment in PubMed Commons below
Postgrad Med J. 2001 May;77(907):323-5.

Importance of family history in type 2 black South African diabetic patients.

Author information

1
Department of Chemical Pathology, Faculty of Medicine, University of Transkei, Private Bag XI, Umtata, South Africa. erasmus@getafix.utr.ac.za

Abstract

OBJECTIVE:

To assess the family history of diabetes in type 2 black South African diabetics with emphasis on the parental phenotype.

DESIGN:

Prospective case-control study in which family histories were obtained from patients.

SETTING:

Diabetic clinic of a provincial teaching hospital in the Transkei region of South Africa.

SUBJECTS:

A total of 1111 type 2 diabetics attending the diabetic clinic and 687 controls.

MAIN OUTCOME MEASURES:

History of diabetes in parents, siblings, maternal and paternal grandparents, aunts, and uncles.

RESULTS:

Altogether 27.3% of diabetic subjects had a family history of diabetes compared with 8.4% in the control group (p<0.01). Among the group with positive family history 82.6% reported only one diabetic family member, while 17.4% reported at least two relatives; 6.6% had a diabetic relative from both maternal and paternal sides, and 87.8% had first degree relative with diabetes. Among them there was a significant maternal aggregation with 64.7% of patients having a diabetic mother compared with 27% who had a diabetic father (p<0.01). No maternal effect was observed among the second and third degree relatives. Patients with positive family history had an earlier onset of diabetes than those without family history (p<0.01).

CONCLUSION:

These data suggest that type 2 diabetes is heritable in black South African diabetics. It is also likely that maternal influences may play an important part.

PMID:
11320276
PMCID:
PMC1742028
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center