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Int J Obes Relat Metab Disord. 2001 Mar;25(3):316-24.

An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.

Author information

1
Obesity Research Center, St Luke's-Roosevelt Hospital Center and Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10025, USA. cnb7@columbia.edu

Abstract

OBJECTIVE:

To examine in overweight humans the short-term safety and efficacy for weight loss of an herbal supplement containing Ma Huang, Guarana and other ingredients.

DESIGN:

An 8 week randomized, double-blind placebo controlled study of a herbal dietary supplement (72 mg/day ephedrine alkaloids and 240 mg/day caffeine).

SUBJECTS:

Overweight men and women (body mass index, > or =29 and < or =35 kg/m2).

MEASUREMENTS:

The primary outcome variable was body weight change. Secondary variables included anthropometric, metabolic and cardiovascular changes.

RESULTS:

Sixty-seven subjects were randomized to either placebo (n=32) or active Ma Huang/Guarana (n=35). Twenty-four subjects in each group completed the study. Active treatment produced significantly (P<0.006) greater loss of weight (X+/-s.d.,-4.0+/-3.4 kg) and fat (-2.1+/-3.0% fat) over the 8-week treatment period than did placebo (-0.8+/-2.4 kg and 0.2+/-2.3% fat). Active treatment also produced greater reductions in hip circumference and serum triglyceride levels. Eight of the 35 actively treated subjects (23%) and none of the 32 placebo-treated control subjects withdrew from the protocol because of potential treatment-related effects. Dry mouth, insomnia and headache were the adverse symptoms reported most frequently by the herbal vs placebo group at the final evaluation visit.

CONCLUSIONS:

This herbal mixture of Ma Huang and Guarana effectively promoted short-term weight and fat loss. Safety with long-term use requires further investigation.

PMID:
11319627
DOI:
10.1038/sj.ijo.0801539
[Indexed for MEDLINE]

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