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Biometrics. 1999 Jun;55(2):463-9.

Finite mixture modeling with mixture outcomes using the EM algorithm.

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Graduate School of Education and Information Studies and Department of Statistics, University of California, Los Angeles, California 90095-1521, USA.


This paper discusses the analysis of an extended finite mixture model where the latent classes corresponding to the mixture components for one set of observed variables influence a second set of observed variables. The research is motivated by a repeated measurement study using a random coefficient model to assess the influence of latent growth trajectory class membership on the probability of a binary disease outcome. More generally, this model can be seen as a combination of latent class modeling and conventional mixture modeling. The EM algorithm is used for estimation. As an illustration, a random-coefficient growth model for the prediction of alcohol dependence from three latent classes of heavy alcohol use trajectories among young adults is analyzed.

[Indexed for MEDLINE]

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