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Diabetologia. 2001 Mar;44(3):363-6.

A locus affecting obesity in human chromosome region 10p12.

Author information

1
Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Blvd., CRB-135b, Philadelphia, PA 19104, USA.

Abstract

AIMS/HYPOTHESIS:

Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes.

METHODS:

We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects.

RESULTS:

We found support for linkage of an obesity phenotype (BMI > or = 27 kg/m2) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005).

CONCLUSION/INTERPRETATION:

These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.

PMID:
11317669
DOI:
10.1007/s001250051627
[Indexed for MEDLINE]

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