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J Craniofac Surg. 2001 Mar;12(2):119-27; discussion 128.

Successful mandibular reconstruction using a BMP bioimplant.

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University of Toronto, 124 Edward Street, Toronto, Ontario M5B 1G6, Canada.


A bone morphogenetic protein bioimplant was used for primary reconstruction of a 6-cm mandibular discontinuity defect, after a segmental resection of an ameloblastoma. Radiographic evidence of new bone induction was seen at 3 and 9 months, postoperatively. A biopsy was taken at 9 months demonstrated viable new bone formation at the bioimplant site. This is the first reported case using a bone morphogenetic protein bioimplant in a human, followed by histological confirmation of new bone.

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