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J Affect Disord. 2001 May;64(2-3):271-5.

Modest adjunctive benefit with transcranial magnetic stimulation in medication-resistant depression.

Author information

1
Complejo Hospitalario GESMA, C/Jesús 40, 07003 Palma de Mallorca, Mallorca, Spain. magato@intersalud.es

Abstract

BACKGROUND:

Controverted results have been obtained using high frequency transcranial magnetic stimulation (HF-rTMS) as an antidepressant treatment.

METHODS:

Forty patients suffering from drug-resistant major depression received ten sessions of HF-rTMS at 90% of the motor threshold on the left prefrontal cortex or sham stimulation, added to their pharmacological treatment, in a randomized double-blind design. In a second open phase, patients still fulfilling criteria of inclusion received ten additional sessions of HF-rTMS at 90 or 110%.

RESULTS:

Real, but not sham HF-rTMS, was associated with a significant decrease in the Hamilton Depression Rating Scale, but only twelve patients decreased more than 50%.

CONCLUSIONS:

Left prefrontal HF-rTMS was effectively associated with antidepressant treatment, although the size effect was small.

LIMITATIONS:

Shortage of the sample and control difficulties of the placebo effect.

CLINICAL RELEVANCE:

Questionable in more than half of the patients studied.

PMID:
11313095
[Indexed for MEDLINE]

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