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Rheumatology (Oxford). 2001 Apr;40(4):406-9.

Renal vascular damage in Japanese patients with systemic sclerosis.

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1
Department of Dermatology, Kanazawa University School of Medicine, Kanazawa 920-8641, Japan.

Abstract

OBJECTIVE:

To evaluate renal vascular damage in Japanese patients with systemic sclerosis (SSc) by colour-flow Doppler ultrasonography.

METHODS:

The pulsatility index (PI) was measured in renal interlobar and segmental arteries by colour-flow Doppler ultrasonography.

RESULTS:

PI values of interlobar arteries were increased in SSc patients (n=53) with normal renal function compared with healthy persons (n=16), systemic lupus erythematosus patients (n=12) and dermatomyositis patients (n=3). SSc patients with elevated PI levels had digital pitting scar, short sublingual frenulum, contracture of phalanges, pulmonary fibrosis, decreased per cent vital capacity, heart involvement, positivity for anti-topoisomerase I antibody, and elevated C-reactive protein more frequently than those with normal PI levels.

CONCLUSION:

Although renal crisis is rare in Japanese SSc patients, our study suggests that latent and subclinical renal damage exists in these patients.

PMID:
11312378
[Indexed for MEDLINE]
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