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J Virol. 2001 May;75(10):4907-11.

Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.

Author information

1
Partners AIDS Research Center & ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract

We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.

PMID:
11312363
PMCID:
PMC114246
DOI:
10.1128/JVI.75.10.4907-4911.2001
[Indexed for MEDLINE]
Free PMC Article

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