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J Med Chem. 2001 Apr 26;44(9):1467-70.

Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.

Author information

1
Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 3BX, UK.

Abstract

New and greatly improved preparations of the 12alpha,1'beta- (5) and 12beta,1'beta- (6) glucuronides of dihydroartemisinin (DHA, 2) are reported using anomeric hydroxy and imidate glucuronate intermediates. Comparison of the synthetic and natural materials shows that the human metabolite of DHA is the 12alpha-epimer 5.

PMID:
11311070
DOI:
10.1021/jm001061a
[Indexed for MEDLINE]

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