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Nature. 2001 Apr 19;410(6831):974-9.

The dynamics of CD4+ T-cell depletion in HIV disease.

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Gladstone Institute of Virology and Immunology, Departments of Medicine and Microbiology and Immunology, University of California at San Francisco, 94141-9100, USA.


The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T cells - sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss.

[Indexed for MEDLINE]

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