Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 2001 Apr 19;410(6831):974-9.

The dynamics of CD4+ T-cell depletion in HIV disease.

Author information

  • 1Gladstone Institute of Virology and Immunology, Departments of Medicine and Microbiology and Immunology, University of California at San Francisco, 94141-9100, USA. mmccune@gladstone.ucsf.edu

Abstract

The size and composition of the CD4+ T-cell population is regulated by balanced proliferation of progenitor cells and death of mature progeny. After infection with the human immunodeficiency virus, this homeostasis is often disturbed and CD4+ T cells are instead depleted. Such depletion cannot result simply from accelerated destruction of mature CD4+ T cells - sources of T-cell production must also fail. Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss.

PMID:
11309627
DOI:
10.1038/35073648
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center