Format

Send to

Choose Destination
Eur J Med Res. 2001 Apr 20;6(4):169-74.

Role of gamma delta T-lymphocytes in HIV infection.

Author information

1
Institute of Immunology, Univeristy of Kiel, Kiel, Germany. kabelitz@immunologie.uni-kiel.de

Abstract

T-lymphocytes expressing the gamma delta T-cell receptor (TCR) comprise a small proportion (1-5%) of circulating CD3(+) T-lymphocytes. While T-cells expressing a V delta 2V gamma 9-encoded TCR dominate among peripheral blood gamma delta T-lymphocytes in healthy individuals, significant alterations in the gamma delta TCR repertoire are observed in HIV-infected persons. These changes are due to the selective preservation (and frequently moderate expansion) of V delta 1-expressing cells and the simultaneous depletion of V delta 2-expressing cells. In this brief review, we discuss the alterations in the gamma delta T-lymphocyte compartment in HIV infection, with special emphasis on the potential role of gamma delta T-cell in the immune defense against HIV.

PMID:
11309229
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center