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Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):332-5.

Homing receptor expression on cord blood T lymphocytes and the development of atopic eczema in infants.

Author information

1
Department of Pediatrics, School of Medicine, Chiba University, Japan. kohnoy@med.m.chiba-u.ac.jp

Abstract

Expression of the gut-homing receptor integrin alphaEbeta7, but not cutaneous lymphocyte-associated antigen (CLA), on milk allergen-stimulated cord blood T lymphocytes precedes the development of milk-induced eczema in early infancy. The data indicate the involvement of integrin alphaEbeta7 in the development of infantile allergic eczema and provide a clue to the avoidance of specific allergens and novel therapy targeting homing receptors in food allergy.

PMID:
11307007
DOI:
10.1159/000053749
[Indexed for MEDLINE]

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