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Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):190-2.

Histamine upregulates Th1 and downregulates Th2 responses due to different patterns of surface histamine 1 and 2 receptor expression.

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1
Wroclaw University of Medicine, Wroclaw, Poland. mjutel@dilnet.wroc.pl

Abstract

Histamine, which acts via G protein-coupled receptors, is an important mediator of immediate hypersensitivity and is also able to influence the nature of T cell responses. We demonstrated that TH1 and Th2 cells express distinct surface histamine receptor patterns and that Th1-type responses are enhanced by histamine, whereas Th2-type responses are negatively regulated, due to different intracellular signals generated by histamine stimulation. These findings account for negative feedback regulation in a wide variety of pathologies.

PMID:
11306965
DOI:
10.1159/000053707
[Indexed for MEDLINE]
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