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Dermatology. 2001;202(2):123-6.

Cutaneous leukocytoclastic vasculitis in dermatomyositis suggests malignancy.

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  • 1Dermatological Clinic, Inselspital, University of Berne, Switzerland. re.hunger@gmx.net

Abstract

BACKGROUND:

Dermatomyositis (DM) is a rare connective tissue disease which has been shown to be associated with an underlying malignancy.

OBJECTIVE:

Evaluation of the prevalence of malignancy in DM at our clinic and search for characteristics of the paraneoplastic form of disease.

METHODS:

Retrospective review of patient files and histology reports over the period from 1991 to 1998.

RESULTS:

23 patients (14 women and 9 men) with DM could be identified in this time period with a median age at diagnosis of 48 years. Malignancies were found in 5 (22%) cases. The skin biopsies of all patients showed features of DM; in 7 cases, a leukocytoclastic vasculitis was detected. Four of the 5 cases with an associated malignancy demonstrated histologically a vasculitis in lesional skin, compared to only 3 out of 18 cases without malignancy (p < 0.05, Fisher's exact test).

CONCLUSION:

Our data suggest that vasculitis in lesional skin biopsies has a predictive value for the presence of underlying malignancy.

PMID:
11306833
DOI:
51611
[PubMed - indexed for MEDLINE]
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