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Trends Cell Biol. 2001 Mar;11(3):130-5.

Integrin-associated protein (CD47) and its ligands.

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Program in Host-Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA.


Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiating heterotrimeric Gi protein signaling that augments the functions of integrins of the beta 1, beta 2 and beta 3 families, thus modulating a range of cell activities including platelet activation, cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.

[Indexed for MEDLINE]

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