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Brain Res. 2001 Apr 20;898(2):350-7.

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.

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Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.


Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain.

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