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Genome Biol. 2001;2(4):REVIEWS1013. Epub 2001 Apr 4.

Genome-wide analysis of protein-DNA interactions in living cells.

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1
Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.

Abstract

Understanding the regulation of gene expression requires an analysis of gene-specific transcription factors. This review highlights recent work that uses protein-DNA crosslinking, immunoprecipitation and DNA microarrays to determine the binding sites for specific transcription factors throughout the yeast genome.

PMID:
11305945
PMCID:
PMC138927
[Indexed for MEDLINE]
Free PMC Article
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