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Eur J Clin Nutr. 2001 Mar;55(3):179-85.

Breast-feeding duration and the risk of malignant diseases in childhood in Sweden.

Author information

1
Department of Oncology, Orebro Medical Center, Sweden. lennart.hardell@orebroll.se

Abstract

OBJECTIVE:

To evaluate childhood cancer in relation to duration of breast-feeding.

SETTING:

Sweden. Records from Child Healthcare Centres were scrutinised regarding information on breast-feeding and other health-related items.

SUBJECTS:

All children aged 0-14 y with a malignant disease (benign brain tumours included) during the time period 1988-91 (n = 962) were identified from the Swedish Cancer Register. An equal number of controls matched for sex and age were selected from the Swedish Birth Register.

RESULTS:

Information was obtained for 835 cases and 860 controls. Overall, duration of breast-feeding did not influence the risk for a malignant disease in this age group. However, breast-feeding > or = 1 month increased the risk for non-Hodgkin's lymphoma (NHL) yielding an odds ratio (OR) 5.5 with 95% confidence interval (CI) 1.2-25. Breast-feeding 1 -< 6 months gave OR 5.1, CI 1.1-24 and > 6 months gave OR 7.0, CI 1.3-37 with a significant trend (P = 0.04). Adjustment for maternal and birth-related co-variates gave similar results. For other malignancies no significant changes of the risk were obtained.

CONCLUSIONS:

Overall, no association between duration of breast-feeding and childhood malignancies was found except for a significantly increased risk for NHL, but this was based on low numbers of cases and needs to be confirmed in other investigations.

PMID:
11305266
[Indexed for MEDLINE]

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