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Neuroreport. 2001 Apr 17;12(5):993-7.

Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation.

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Stanford University Center for Narcolepsy, Palo Alto, CA 94304 USA.


Hypocretin-1 is consistently detectable in the CSF of healthy human subjects, but is absent in narcoleptics. However, functional roles of CSF hypocretin are largely unknown. We examined fluctuation of CSF hypocretin-1 across 24 h and in response to food restriction in rats. Hypocretin-1 levels were high during the dark period when animals were active, but decreased by 40% toward the end of the light (rest) period. After 72 h food deprivation hypocretin-1 levels during the rest phase increased to concentrations similar to those seen during the baseline active phase; however, no increase in response to food deprivation was observed during the active phase. These results indicate an important link between circadian control of sleep and energy homeostasis via the hypocretin system.

[Indexed for MEDLINE]

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