Lignans as anti-tumor-promoter from the seeds of Hernandia ovigera

C Ito; M Itoigawa; M Ogata; X Y Mou; H Tokuda; H Nishino; H Furukawa

doi:10.1055/s-2001-11501

Lignans as anti-tumor-promoter from the seeds of Hernandia ovigera

Planta Med. 2001 Mar;67(2):166-8. doi: 10.1055/s-2001-11501.

Authors

C Ito, M Itoigawa, M Ogata, X Y Mou, H Tokuda, H Nishino, H Furukawa

PMID: 11301868
DOI: 10.1055/s-2001-11501

Abstract

Seven lignans (2-8) isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC50 470-590 mol ratio/32 pmol TPA. The data demonstrated that these lignans might be valuable anti-tumor-promoters.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anticarcinogenic Agents / isolation & purification
Anticarcinogenic Agents / therapeutic use*
Antigens, Viral / drug effects*
Humans
Lignans / isolation & purification
Lignans / therapeutic use*
Molecular Structure
Plants, Medicinal / chemistry*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Seeds / chemistry
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Anticarcinogenic Agents
Antigens, Viral
Epstein-Barr virus early antigen
Lignans
Tetradecanoylphorbol Acetate