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Br J Surg. 2001 Apr;88(4):564-8.

Expression of gastrin in developing gastric adenocarcinoma.

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1
Academic Unit of Cancer Studies, Section of Surgery, University Hospital, Nottingham, UK.

Abstract

BACKGROUND:

A stepwise progression through premalignant stages has been identified for the intestinal type of gastric carcinoma. As gastrin has been identified as a growth factor for the intestinal type of gastric adenocarcinoma, the aim of this study was to investigate whether gastrin is expressed in premalignant gastric conditions.

METHODS:

Ninety archival samples of atrophic gastritis, intestinal metaplasia, mild gastric epithelial dysplasia, moderate gastric epithelial dysplasia, severe gastric epithelial dysplasia and intestinal-type gastric adenocarcinoma were obtained. Immunocytochemistry was performed using antibodies directed against gastrin and its post-translational precursors, and the gastrin/cholecystokinin B receptor. Positive staining was identified using the avidin--biotin immunoperoxidase method and quantified using an image analysis system.

RESULTS:

Gastrin and its receptor were shown to be expressed in specimens of atrophic gastritis, intestinal metaplasia, epithelial dysplasia and the intestinal type of gastric carcinoma.

CONCLUSION:

Gastrin seems to be an important growth factor in gastric carcinogenesis.

[Indexed for MEDLINE]

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