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J Appl Microbiol. 2001 Mar;90(3):343-52.

Establishment of orally-administered Lactobacillus gasseri SBT2055SR in the gastrointestinal tract of humans and its influence on intestinal microflora and metabolism.

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1
Technology and Research Institute, Snow Brand Milk Products Co., Ltd, Kawagoe, Saitama, Japan. ht4s-fjwr@asahi-net.or.jp

Abstract

AIMS:

To investigate the fate of a streptomycin-rifampicin-resistant variant of Lactobacillus gasseri SBT2055 (LG2055SR) and the influence of its oral administration on the composition and metabolism of the intestinal microflora.

METHODS AND RESULTS:

Intestinal passage of LG2055SR was monitored by a combination of selection with antibiotics and identification by a randomly amplified polymorphic DNA (RAPD)-PCR METHOD: Composition of intestinal microflora was analysed by the method developed by Mitsuoka et al. (1965, 1974). Establishment of orally-administered LG2055SR in the human intestine was confirmed in this study. LG2055SR ingestion specifically lowered faecal populations of Staphylococcus and faecal contents of p-cresol.

CONCLUSION:

LG2055SR and its parent strain, LG2055, are considered to be appropriate candidates for probiotics.

SIGNIFICANCE AND IMPACT OF THE STUDY:

It is clarified that LG2055SR has the ability to establish in the human gastrointestinal tract and alters the composition and metabolism of the intestinal microflora and physical characteristics of faeces.

PMID:
11298228
[Indexed for MEDLINE]
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