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Curr Opin Struct Biol. 2001 Apr;11(2):224-30.

Steered molecular dynamics and mechanical functions of proteins.

Author information

1
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Abstract

Atomic force microscopy of single molecules, steered molecular dynamics and the theory of stochastic processes have established a new field that investigates mechanical functions of proteins, such as ligand-receptor binding/unbinding and elasticity of muscle proteins during stretching. The combination of these methods yields information on the energy landscape that controls mechanical function and on the force-bearing components of proteins, as well as on the underlying physical mechanisms.

PMID:
11297932
[Indexed for MEDLINE]

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