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Curr Opin Struct Biol. 2001 Apr;11(2):155-62.

Bacterial RNA polymerase.

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The Rockefeller University, Box 224, 1230 York Avenue, New York, NY 10021, USA.


The recently determined crystal structure of a bacterial core RNA polymerase (RNAP) provides the first glimpse of this family of evolutionarily conserved cellular RNAPs. Using the structure as a framework, a consistent picture of protein-nucleic acid interactions in transcription complexes has been accumulated from cross-linking experiments. The molecule can be viewed as a molecular machine, with distinct structural features hypothesized to perform specific functions. Comparison with the alpha-carbon backbone of a eukaryotic RNAP reveals close structural similarity.

[Indexed for MEDLINE]

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