New t(11;12)(q12;q11) characterized by RxFISH in a patient with T-cell large granular lymphocyte leukemia

M Salido; F Solé; B Espinet; L Zamora; S Woessner; L Florensa

doi:10.1016/s0165-4608(00)00357-5

New t(11;12)(q12;q11) characterized by RxFISH in a patient with T-cell large granular lymphocyte leukemia

Cancer Genet Cytogenet. 2001 Feb;125(1):70-3. doi: 10.1016/s0165-4608(00)00357-5.

Authors

M Salido¹, F Solé, B Espinet, L Zamora, S Woessner, L Florensa

Affiliation

¹ Laboratori de Citologia Hematològica/Laboratori de Referència de Catalunya, Unitat d'Hematologia 1973, Hospital del Mar, IMAS, IMIM, Barcelona, Spain. e0037@imas.imim.es

PMID: 11297771
DOI: 10.1016/s0165-4608(00)00357-5

Abstract

Chromosomal abnormalities in patients with large granular lymphocyte leukemia (LGLL) are rare. Herein we present a novel cytogenetic abnormality t(11;12)(q12;q11) in a patient with LGLL identified by cross-species color banding (RxFISH). The application of RxFISH allowed the rapid and easy identification of a chromosome rearrangement that was not recognized by conventional cytogenetics. Therefore, RxFISH is a suitable complement to, but not a replacement for, conventional cytogenetics.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 12*
Humans
In Situ Hybridization, Fluorescence / methods*
Karyotyping
Leukemia, T-Cell / genetics*
Male
Translocation, Genetic*