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Lasers Surg Med. 2001;28(3):204-11.

Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation.

Author information

1
Department of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. oronu@post.tau.ac.il

Abstract

BACKGROUND AND OBJECTIVE:

The aim of the present study was to investigate the possibility that low-energy laser irradiation attenuates infarct size formation after induction of chronic myocardial infarction (MI) in small and large experimental animals.

STUDY DESIGN/MATERIALS AND METHODS:

Laser irradiation was applied to the infarcted area of rats and dogs at various power densities (2.5 to 20 mW/cm(2)) after occlusion of the coronary artery.

RESULTS:

In infarcted laser-irradiated rats that received laser irradiation immediately and 3 days after MI at energy densities of 2.5, 6, and 20 mW/cm(2), there was a 14%, 62% (significant; P < 0.05), and 2.8% reduction of infarct size (14 days after MI) relative to non--laser-irradiated rats, respectively. In dogs, a 49% (significant; P < 0.01) reduction of infarct size was achieved.

CONCLUSION:

The results of the present study indicate that delivery of low-energy laser irradiation to infarcted myocardium in rats and dogs has a profound effect on the infarct size after MI.

PMID:
11295753
DOI:
10.1002/lsm.1039
[Indexed for MEDLINE]

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