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Trends Biochem Sci. 2001 Apr;26(4):257-65.

Transmembrane signaling in bacterial chemoreceptors.

Author information

1
Department of Chemistry and Biochemistry, University of Colorado, 80309-0215, Boulder, CO, USA. falke@colorado.edu

Abstract

Bacterial chemoreceptors mediate chemotaxis by recognizing specific chemicals and regulating a noncovalently associated histidine kinase. Ligand binding to the external domain of the membrane-spanning receptor generates a transmembrane signal that modulates kinase activity inside the cell. This transmembrane signaling is being investigated by novel strategies, which have revealed a remarkably subtle conformational signal carried by a signaling helix that spans the entire length of the >350-A-long receptor. Multiple, independent lines of evidence indicate that, in the periplasmic and transmembrane domains, conformational signaling is a piston-type sliding of the signaling helix towards the cytoplasm.

PMID:
11295559
PMCID:
PMC2895674
DOI:
10.1016/s0968-0004(00)01770-9
[Indexed for MEDLINE]
Free PMC Article

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