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Bioorg Med Chem Lett. 2001 Apr 9;11(7):871-4.

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.

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Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA.


Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.

[Indexed for MEDLINE]

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