Format

Send to

Choose Destination
See comment in PubMed Commons below
IEEE Trans Med Imaging. 2001 Jan;20(1):70-80.

Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex.

Author information

1
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA. fischl@nmr.mgh.harvard.edu

Abstract

Highly accurate surface models of the cerebral cortex are becoming increasingly important as tools in the investigation of the functional organization of the human brain. The construction of such models is difficult using current neuroimaging technology due to the high degree of cortical folding. Even single voxel misclassifications can result in erroneous connections being created between adjacent banks of a sulcus, resulting in a topologically inaccurate model. These topological defects cause the cortical model to no longer be homeomorphic to a sheet, preventing the accurate inflation, flattening, or spherical morphing of the reconstructed cortex. Surface deformation techniques can guarantee the topological correctness of a model, but are time-consuming and may result in geometrically inaccurate models. In order to address this need we have developed a technique for taking a model of the cortex, detecting and fixing the topological defects while leaving that majority of the model intact, resulting in a surface that is both geometrically accurate and topologically correct.

PMID:
11293693
DOI:
10.1109/42.906426
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society
    Loading ...
    Support Center