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Lancet. 2001 Mar 31;357(9261):1013-4.

Pitfalls in the use of thyrotropin concentration as a first-line thyroid-function test.

Abstract

Measurement of thyrotropin concentration alone as a first-line thyroid-function test fails to indicate hypopituitarism in a number of patients. Using a combination of thyrotropin and thyroxine assays, we analysed 56,000 tests for a population of 471,000 over 12 months. 15 patients with clinically unsuspected hypopituitarism were detected, indicating that the occurrence of hypopituitarism might be underestimated.

PMID:
11293597
DOI:
10.1016/S0140-6736(00)04248-3
[Indexed for MEDLINE]

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