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Int J Pharm. 2001 Apr 17;217(1-2):249-53.

Electroporation of the skin to deliver antigen by using a piezo ceramic gas igniter.

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National Institute of Immunology, Aruna Asaf Ali Marg, 110067, New Delhi, India.


The static electricity generated by triggering a piezo gas igniter is shown to cause electroporation of the skin to deliver antigen. Mice were immunized with chicken albumin by electroporation using a piezo gas igniter and in another experiment, the gas igniter was replaced by a power supply. In both the groups identical immune responses were generated. The change in impedance of the skin of a mice after applying high voltage electrical pulses from a power supply and that with a gas igniter were found to be similar. The piezo gas igniter is an inexpensive and easily available device. It is much more user 'friendly' than a power supply used for electroporation and it may be viewed as a replacement for a syringe with a needle.

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