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Semin Cell Dev Biol. 2001 Apr;12(2):99-106.

Heparan sulfate proteoglycans in the nervous system: their diverse roles in neurogenesis, axon guidance, and synaptogenesis.

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1
Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. yyamaguchi@burnham.org

Abstract

Development of the mammalian nervous system involves generation of neurons from neural stem cells, migration of generated neurons toward genetically determined locations, extension of axons and dendrites, and establishment of neuronal connectivity. Recent progresses revealed diverse role of heparan sulfate proteoglycans in these processes. This article reviews our current knowledge about the functional roles of heparan sulfate proteoglycans in three critical events in mammalian neural development, namely neurogenesis, axon guidance, and synapse development.

PMID:
11292375
DOI:
10.1006/scdb.2000.0238
[Indexed for MEDLINE]
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