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Cell Mol Life Sci. 2001 Feb;58(2):278-88.

Molecular genetic analysis of the calcineurin signaling pathways.

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1
Department of Pharmacology, Kobe University School of Medicine, Japan.

Abstract

Calcineurin is a Ca2+- and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the powerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T cell activation, muscle hypertrophy, memory development, glucan synthesis, ion homeostasis, and cell cycle control. Notably, specific transcription factors have been shown to play a key role in regulating these functions, and their calcineurin-mediated dephosphorylation and nuclear translocation appear to be a central event in the signal transduction pathways. This review focuses on recent progress in these areas and discusses the evidence for cross-talk between calcineurin and other signaling pathways.

PMID:
11289309
DOI:
10.1007/PL00000855
[Indexed for MEDLINE]

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