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Biochim Biophys Acta. 2001 Apr 3;1526(1):10-2.

Oxidative stress increases MICA and MICB gene expression in the human colon carcinoma cell line (CaCo-2).

Author information

1
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan. yamak@belle.shiga-med.ac.jp

Abstract

The human major histocompatibility complex class I chain-related A gene (MICA) and the MICB gene are newly identified members of the major histocompatibility complex class I chain-related gene family. We demonstrate here that oxidative stress, induced by H(2)O(2), promoted MICA (2.2-fold) and MICB (3.8-fold) gene expression using the human colon carcinoma cell line (CaCo-2) and semi-quantitative RT-PCR.

PMID:
11287116
DOI:
10.1016/s0304-4165(01)00099-x
[Indexed for MEDLINE]

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