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Trends Immunol. 2001 Jan;22(1):21-6.

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.

Author information

1
Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131, Mainz, Germany. neurath@1-med.klinik.uni-mainz.de

Erratum in

  • Trends Immunol 2001 Apr;22(4):225.

Abstract

T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.

PMID:
11286687
[Indexed for MEDLINE]

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