Send to

Choose Destination
Trends Immunol. 2001 Jan;22(1):21-6.

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.

Author information

Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131, Mainz, Germany.

Erratum in

  • Trends Immunol 2001 Apr;22(4):225.


T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center