Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

C D Tsoukas; J A Grasis; K A Ching; Y Kawakami; T Kawakami

doi:10.1016/s1471-4906(00)01795-6

Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

Trends Immunol. 2001 Jan;22(1):17-20. doi: 10.1016/s1471-4906(00)01795-6.

Authors

C D Tsoukas¹, J A Grasis, K A Ching, Y Kawakami, T Kawakami

Affiliation

¹ Department of Biology and the Molecular Biology Institute, San Diego State University, CA 92182, USA. ctsoukas@sunstroke.sdsu.edu

PMID: 11286686
DOI: 10.1016/s1471-4906(00)01795-6

Abstract

Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca(2+), PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Calcium Signaling*
Cytoskeleton / enzymology*
Cytoskeleton / immunology*
Enzyme Activation / immunology
Humans
Protein-Tyrosine Kinases / metabolism*
Receptors, Antigen, T-Cell / physiology*
T-Lymphocytes / enzymology
T-Lymphocytes / metabolism

Substances

Receptors, Antigen, T-Cell
Protein-Tyrosine Kinases
emt protein-tyrosine kinase

Abstract

Publication types

MeSH terms

Substances

Grants and funding