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Curr Rheumatol Rep. 2001 Apr;3(2):101-6.

An update on the science and therapy of obesity and its relationship to osteoarthritis.

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Columbia University, Division of Endocrinology, 630 West 168th Street, Black Building Room 905, New York, NY 10032, USA.


Obesity and osteoarthritis are two commonly encountered clinical problems that can lead to significant physical and emotional disability. This report examines the association between obesity and osteoarthritis, and discusses potential mechanisms by which obesity influences osteoarthritis. Special attention is devoted to reviewing the molecular and genetic mechanisms that underlie the development of clinical obesity. Improved understanding of obesity will hopefully lead to improved treatment and subsequent amelioration of this important risk factor for osteoarthritis.

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