Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes

Mol Genet Metab. 2001 Apr;72(4):356-9. doi: 10.1006/mgme.2000.3136.

Abstract

SOX13 is a member of the SOX family of transcription factors that encodes the type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q31.3-32.1 near a region containing a susceptibility locus for type 1 diabetes. SOX13 was assessed as a candidate susceptibility gene. Analysis of the SOX13 gene identified a number of single nucleotide polymorphisms and a polymorphic CA dinucleotide repeat. Linkage and association studies indicate that SOX13 is unlikely to make a substantial contribution to type 1 diabetes susceptibility.

MeSH terms

  • Autoantigens / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1 / genetics
  • DNA / metabolism
  • Diabetes Mellitus, Type 1 / genetics*
  • Family
  • Gene Frequency
  • Genotype
  • High Mobility Group Proteins / genetics*
  • Humans
  • Polymorphism, Single Nucleotide
  • SOXD Transcription Factors

Substances

  • Autoantigens
  • High Mobility Group Proteins
  • SOX13 protein, human
  • SOXD Transcription Factors
  • DNA