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Nat Biotechnol. 2001 Apr;19(4):327-31.

Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands.

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1
Institut für Diagnostikforschung GmbH an der Freien Universität Berlin, 14050 Berlin, Germany.

Abstract

We report here the in vivo diagnostic use of a peptide-dye conjugate consisting of a cyanine dye and the somatostatin analog octreotate as a contrast agent for optical tumor imaging. When used in whole-body in vivo imaging of mouse xenografts, indotricarbocyanine-octreotate accumulated in tumor tissue. Tumor fluorescence rapidly increased and was more than threefold higher than that of normal tissue from 3 to 24 h after application. The targeting conjugate was also specifically internalized by primary human neuroendocrine tumor cells. This imaging approach, combining the specificity of ligand/receptor interaction with near-infrared fluorescence detection, may be applied in various other fields of cancer diagnosis.

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PMID:
11283589
DOI:
10.1038/86707
[Indexed for MEDLINE]

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