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Annu Rev Neurosci. 2001;24:239-62.

Paraneoplastic neurologic disease antigens: RNA-binding proteins and signaling proteins in neuronal degeneration.

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1
Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, New York 10021, USA. musunuk@rockvax.rockefeller.edu

Abstract

Studies of the disorders known as paraneoplastic neurologic degenerations exemplify the successful application of modern molecular biological techniques to diseases, yielding, even for these extremely rare disorders, wide-ranging insight into basic neurobiology, tumor immunity, and autoimmune neurologic disease. Immune responses to paraneoplastic neurologic degeneration antigens, also called onconeural antigens, have been exploited to clone and characterize a number of neuron-specific proteins, including several RNA-binding proteins and new kinds of signaling molecules. The biology and functions of these proteins are reviewed, and a model in which their functions are related to the pathogenesis of autoimmune neurologic disease is discussed.

PMID:
11283311
DOI:
10.1146/annurev.neuro.24.1.239
[Indexed for MEDLINE]
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