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Trends Parasitol. 2001 Apr;17(4):183-8.

The dangers of using single locus markers in parasite epidemiology: Ascaris as a case study.

Author information

1
Southwest Foundation for Biomedical Research, San Antonio, TX, USA. tanderso@darwin.sfbr.org

Abstract

Molecular markers are used widely to discriminate between closely related species of parasites, and in many cases a single locus is used for this purpose. This article aims to show how molecular data derived from a single genetic marker or linkage group - in this case mitochondrial DNA - can lead to ambiguous conclusions and to illustrate how a multilocus approach has enhanced our understanding of the epidemiology of two closely related parasites, the nematodes Ascaris suum, which infects pigs, and Ascaris lumbicoides, which infects humans.

PMID:
11282508
DOI:
10.1016/s1471-4922(00)01944-9
[Indexed for MEDLINE]

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