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Int J Antimicrob Agents. 2001 Mar;17(3):229-31.

In vitro activity of four fluoroquinolones against Mycobacterium tuberculosis.

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  • 1Section of Microbiology, Hospital General Universitario de Elche, Universidad Miguel Hernández, 03202 Elche Alicante, Spain.


The in vitro activity of ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin against strains of Mycobacterium tuberculosis was studied. Moxifloxacin and levofloxacin showed the greatest activity having an MIC(90) of 1 mg/l. The MIC(90) for ofloxacin was 2 mg/l and for ciprofloxacin 4 mg/l. Further studies should be made to determine the role played by these compounds in the treatment of tuberculosis.

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