Cortamidine oxide, a novel disulfide metabolite from the New Zealand basidiomycete (mushroom) Cortinarius species

G M Nicholas; J W Blunt; M H Munro

doi:10.1021/np000408+

Cortamidine oxide, a novel disulfide metabolite from the New Zealand basidiomycete (mushroom) Cortinarius species

J Nat Prod. 2001 Mar;64(3):341-4. doi: 10.1021/np000408+.

Authors

G M Nicholas¹, J W Blunt, M H Munro

Affiliation

¹ Department of Chemistry, University of Canterbury, PB 4800, Christchurch, New Zealand.

PMID: 11277751
DOI: 10.1021/np000408+

Abstract

Three disulfide metabolites were isolated from the fruiting bodies of the basidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zealand. The structures of these compounds were determined as the unsymmetrical disulfide cortamidine oxide (1), 2,2'-dithiobis(pyridine N-oxide) (2), and the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobial activity and cytotoxicity. 2,2'-Dithiobis(pyridine N-oxide) (2) and the symmetrical disulfide 3 are assumed to be artifacts of the isolation procedure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Agaricales / metabolism*
Animals
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / metabolism
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / metabolism
Disulfides / isolation & purification*
Disulfides / metabolism
Leukemia P388
New Zealand
Oxides / chemistry
Oxides / isolation & purification*
Oxides / metabolism
Oxides / pharmacology
Pyridines / chemistry
Pyridines / isolation & purification*
Pyridines / metabolism
Pyridines / pharmacology

Substances

Anti-Infective Agents
Antineoplastic Agents
Disulfides
Oxides
Pyridines
cortamidine oxide