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Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4.

NO-independent stimulators of soluble guanylate cyclase.

Author information

1
Institute of Medicinal Chemistry, Pharma Research Centre, Bayer AG, Wuppertal, FRG. alexander.straub.as@bayer-ag.de

Abstract

SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application.

PMID:
11277519
DOI:
10.1016/s0960-894x(01)00073-7
[Indexed for MEDLINE]

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